皆さんこんにちは。
東海も梅雨に入りましたね。
雨の多い季節ですが、インドアでも楽しいことを
見つけていきたいです。
さて、今回もMTAに関する文献です。
前回は封鎖性についての文献でしたが
今回は生体適合性についてです。
The purpose of the present study was to compare the cytotoxicity of mineral trioxide aggregate (MTA) to other commonly used retrofilling materials,Super-EBA and amalgam. This was accomplished using a cell viability assay for mitochondrial
dehydrogenase activity in human periodontal ligament fibroblasts after 24-hr exposure to extracts of varying concentrations of the test materials,
in both freshly mixed and 24-hr set states.Methyl methacrylate 2% (vol/vol) served as the positive control, and complete culture medium served as the negative control. Differences in mean cell viability values were assessed by ANOVA (p <0.05). In the freshly mixed state, the sequence of toxicity was amalgam > Super-EBA > MTA. In the 24-hr set state the sequence of toxicity at a low extract concentration was Super-EBA > MTA,amalgam, and Super-EBA > amalgam > MTA at a higher extract concentration. This study supports the use of MTA in the root-end environment.
つまり
MTAとSuperEBAセメントと
MTAセメントそれぞれの溶出液
を添加した培養液中で
ヒト歯根膜細胞を24時間培養した所
細胞の生存率はMTAセメントが最も高かったということです。
引用文献
Karl Keiser, DDS, MS, C. Chad Johnson, BS, and David A. Tipton, DDS, PhD
Cytotoxicity of Mineral Trioxide Aggregate Using Human Periodontal Ligament Fibroblasts
J Endod 2000;26(5):288-291