皆さんこんにちは。

前回はNaOClの副作用についての論文でしたが、

今回は効能の一つである抗菌作用の観点から、

NaOClの最適濃度を考えた論文について紹介します。

Antimicrobial effect of root canal débridement in teeth with immature root. A clinical and microbiologic study.

The aim of present investigation was to compare the antibacterial effect of biochemical root canal cleansing in permanent non-vital upper incisors with immature with those with mature root. The material comprised three groups made up of 34, 46 and 28 teeth in which the mechanical cleansing was accompanied by flushing with sterile saline and sodium hypochlorite solutions giving 0.5 or 5.0% active chloride, respectively. Samples were taken in root canals initially after removal of necrotic tissue and after completed cleansing, transferred to solid and liquid media for aerobically and anaerobically and incubated until growth appeared or up to 10 days. The microorganisms were identified by biochemical tests and gas-chromatographic analysis. The antibacterial effect of mechanical cleansing with sterile saline was very low (9%) and limited to the teeth with mature root. The flushing with sodium hypochlorite increased the antibacterial effect to about 25%. No statistical difference was found in the antibacterial effect between flushing with 0.5 % or 5.0% sodium hypochlorite solutions. （略）

つまり、失活した上顎切歯根管に対して、

①生食、②0.5%ヒポクロ、③5.0%ヒポクロの3種類で

それぞれ洗浄を行いながら機械的拡大を行った所、

抗菌効果は①は9%と低かったのに対し、

②と③は共に25%の効果を示し、

②と③の効果に統計的に有意差は認められなかったということです。

引用文献

Odontol Revy. 1976;27(1):1-10.