今回もガッタパーチャ溶解剤についての文献です。

クロロホルムやキシレンに代わる生体為害性の少ない代替剤として

Hemo-Deの溶解性能を調べています。

Hemo-Deは前回登場したGPソルベントと同じく

d-リモネンが主成分です。

The putative hazardous nature of chloroform and xylene implies that safer substitutes should be considered. Standard cylindrical gutta-percha samples were immersed in Hemo-De, a xylene substitute, for 60 s at 37 degrees C. Weight loss of a sample, after drying, was used as a measure of its solubility. Master and accessory cone gutta-percha of three brands were compared. The highest solubility of all kinds of gutta-percha was in chloroform, which served as a positive control. The average solubility of all samples in xylene and Hemo-De was 61% and 52% of that in chloroform, respectively. DMS gutta-percha was more soluble than of Hygienic and DeTrey. Master cone gutta-percha of all brands was more soluble than that of their accessory cones. These results indicate that (a) large differences exist in the solubility of gutta-percha and (b) Hemo-De dissolved gutta-percha in a range similar to that of xylene and may be considered as a potential substitute for this organic solvent.

つまり

クロロホルムはキシレンやHemo-Deと比較して、有意に優れた溶解性能を示したが

キシレンとHemo-Deの溶解性能はクロロホルムに対して

それぞれ61％と52％で、近似していた。

以上より、Hemo-Deはキシレンやクロロホルムの代替剤になり得ると考えられた

ということです。

細菌はガッタパーチャ表面を足場として増殖することが分かっていますので

エビデンスのある薬品・手法を用いて

安全性が高く、かつ効率的なガッタパーチャの除去を目指していきたいです。

引用文献

Metzger Z, Marian-Kfir V, Tamse A.

Gutta-percha softening: “Hemo-De” as a xylene substitute.

J Endod. 2000 Jul;26(7):385-8.