今回は口腔内状況と心筋梗塞発症の

関連性を検討した文献です。

フィンランドにて心筋梗塞罹患患者

102人と健常者100人に対し、後ろ向き研究

をしています。

口腔内状況の項目として

カリエスの有無、歯周病の有無

根尖病巣の有無、智歯周囲炎の有無を調査しています。

Known risk factors for coronary heart disease do not explain all of the clinical and epidemiological features of the disease. To examine the role of chronic bacterial infections as risk factors for the disease the association between poor dental health and acute myocardial infarction was investigated in two separate case-control studies of a total of 100 patients with acute myocardial infarction and 102 controls selected from the community at random. Dental health was graded by using two indexes, one of which was assessed blind. Based on these indexes dental health was significantly worse in patients with acute myocardial infarction than in controls. The association remained valid after adjustment for age, social class, smoking, serum lipid concentrations, and the presence of diabetes. Further prospective studies are required in different populations to confirm the association and to elucidate its nature.

結果は、健常者に比較して心筋梗塞罹患患者は

有意に口腔内状態が悪い。

結論は口腔内状態と心筋梗塞発症に関連性が

確認されたということです。

歯周病が全身的な炎症応答の亢進と血管内皮細胞に

影響を及ぼすことは分かっており、それを

肯定する文献でした。

.

引用文献

Mattila KJ, Nieminen MS, Valtonen VV, Rasi VP, Kesäniemi YA, Syrjälä SL, Jungell PS, Isoluoma M, Hietaniemi K, Jokinen MJ.

Association between dental health and acute myocardial infarction.

BMJ. 1989 Mar 25;298(6676):779-81.