今回は広汎型慢性歯周炎を合併した
血糖コントロール不良な2型糖尿病患者に対する
クロルヘキシジン洗口を伴うFMDの臨床的効果を
評価しています。
広汎型慢性歯周炎患者38名
(テスト群：FMD19名、コントロール群：FMSRP19名
FMDでの抗菌療法は60日間の1％CHXゲルの歯周ポケット内投与
0.12%CHX溶液での洗口。
FMSRPは24時間以内の全額SRP)
に対しPPD、アタッチメントレベル、BOP、空腹時血糖
HbA1cを評価しています。
The aim of this randomized controlled clinical trial was to evaluate the clinical effects of chlorhexidine (CHX) application in a full-mouth disinfection (FMD) protocol in poorly controlled type-2 diabetic subjects with generalized chronic periodontitis.
Thirty-eight subjects were randomly assigned into FMD group (n=19): full-mouth scaling and root planing (FMSRP) within 24 h + local application of CHX gel + CHX rinses for 60 days or Control group (n = 19): FMSRP within 24 h + local application of placebo gel + placebo rinses for 60 days. Clinical parameters, glycated haemoglobin and fasting plasma glucose were assessed at baseline, 3, 6 and 12 months post-therapies.
All clinical parameters improved significantly at 3, 6 and 12 months post-therapies for both groups (p < 0.05). There were no significant differences between groups for any clinical parameters, and glycemic condition at any time-point (p > 0.05).
The treatments did not differ with respect to clinical parameters, including the primary outcome variable (i.e. changes in clinical attachment level in deep pockets), for up to 12 months post-treatments.
結果は
両群ともに3,6,12ヶ月後全ての評価項目で
有意な改善が認められたが、群間では有意差はなかった。
結論として
広汎型慢性歯周炎患者を合併した2型糖尿病患者
に対するCHXの局所抗菌療法併用の有無による
歯周組織の改善効果に有意差は認められなかった
ということです。
．
引用文献
Santos VR1, Lima JA, Miranda TS, Gonçalves TE, Figueiredo LC, Faveri M, Duarte PM.
Full-mouth disinfection as a therapeutic protocol for type-2 diabetic subjects with chronic periodontitis: twelve-month clinical outcomes: a randomized controlled clinical trial.
J Clin Periodontol. 2013 Feb;40(2):155-62.