今回はHbA1cと歯周病の程度を比較した文献です。
糖尿病の診断は血糖値とHbA1cの数値で行われ
HbA1cは6.5%以上が基準となります。
この研究では、歯周病を発症していない5856名の対象者
(その内、HbAIc6.5%未満の人は5706名
6.5%以上の人(糖尿病または糖尿病疑い)は150名)
に対して5年間調査を行い
両者のCPIを比較しています。
The objective of this study was to assess whether there is a bi-directional relationship between periodontal status and diabetes.
Study 1 included 5,856 people without periodontal pockets of ≥ 4 mm at baseline. Relative risk was estimated for the 5-year incidence of periodontal pockets of ≥ 4 mm (CPI scores 3 and 4, with the CPI probe), in individuals with glycated hemoglobin (HbA1c) levels of ≥ 6.5% at baseline.
Study 2 included 6,125 people with HbA1c < 6.5% at baseline. The relative risk was assessed for elevation of HbA1c levels in 5 years, with baseline periodontal status, assessed by CPI.
Relative risk of developing a periodontal pocket was 1.17 (p = 0.038) times greater in those with HbA1c of ≥ 6.5% at baseline, adjusted for body mass index (BMI), smoking status, sex, and age.
Relative risks for having HbA1c ≥ 6.5% at 5-year follow-up in groups with periodontal pockets of 4 to 5 mm and ≥ 6 mm at baseline were 2.47 (p = 0.122) and 3.45 (p = 0.037), respectively, adjusted for BMI, alcohol consumption, smoking status, sex, and age. The risk of developing periodontal disease was associated with levels of HbA1c, and the risk of elevations of HbA1c was associated with developing periodontal pockets of more than 4 mm.
つまり
HbA1c6.5%以上の人がCPIコード3または4になる
相対危険度は
性別や年齢、喫煙、BMI調整後1.17であり
HbA1c6.5%以上であることは歯周病を
発症するリスクを高める
ということが分かりました。
引用文献
Morita I1, Inagaki K, Nakamura F, Noguchi T, Matsubara T, Yoshii S, Nakagaki H, Mizuno K, Sheiham A, Sabbah W.
Relationship between periodontal status and levels of glycated hemoglobin.
J Dent Res. 2012 Feb;91(2):161-6.